Progeria

Progeria






Progeria is a disorder of genetic origin that causes small children (1-2 years) to become aged rapidly. This disorder is also called Hutchinson Gilford progeria syndrome. The infant will appear to be normal during birth and even until one year. The symptoms like hair loss and slow growth rate will appear after that and such children will live only for short period. Mostly they die during young ages before 20 years but some live longer than that. Very often, Stroke or severe heart problem will be the cause of death in such children.

Symptoms :

For many infants, the initial symptoms will begin even before the child completes his first year. Suddenly the weight and height of the child will decline rapidly. Motor development will be regular but physical changes will be prominent. The face will be narrow, with a Broken Nose and there will be loss of hair on the scalp and even on the eyelashes. The skin will not be soft like other children but it will become tight or hardened. This is more particular on the hands and feet.

The size of the head will not be compatible with that of the child’s face. He will have prominent eyes, thin lips and his veins will be visible. His joints will be very stiff but will have normal voice. His heartbeat will not be regular and most often the children will be insulin resistant.

Causes :

Progeria is caused by gene mutation of the lamin A gene. This gene is responsible for holding the cells together and this missing gene may cause the aging process rapidly in some children. This particular type of gene mutation is not found in either father or mother. Some syndromes of progeria run in families passed on to the offspring from the parent.

Complications :

Apart from physical abnormality children diagnosed with progeria will have short life expectancy. Often these children will develop hardening of arteries. Arteries will become narrow and shrink thus restricting normal blood flow. Mostly they die of atherosclerosis or other types of cardiovascular problems.

Tests :

It is easy to identify children with progeria based on several physical symptoms. The doctor will conduct genetic test like LMNA for confirming the illness.

Treatment :

Progeria is congenital and hence there is no treatment or remedy for the disorder. Only certain symptoms can be managed by medications and therapy. For children with cardiovascular diseases, bypass surgery is done or open heart surgery is performed, depending on the individual child’s case.

Low dosage of aspirin can be given to such children to prevent massive Heart Attack or stroke. Anticoagulants or similar medicines are given for controlling cholesterol. Hormone therapy can be given to stimulate the arrested growth in children having progeria syndrome. Gradual increase in height and weight can be seen after taking hormone therapy. Occupational therapy is given for reducing joint stiffness and for repairing hip dislocation. Research is still going on for correcting the cell defects through FTI famesyltransferase inhibitors.

Home Remedies :

Always ensure that your child is given plenty of fluids like milk/juice or water, since dehydration is a common problem in such children. Since nutrition and gaining weight can be problem, give small frequent meals for your child. Motivate him/her for engaging in physical activity. Give him/her regular immunization since the child can develop risk of getting more infections.

Pictures of Progeria :

Images, Pics, Pictures and Photos of Progeria

Coping and Support :

It will really be devastating for the mother and father to know that their child is having progeria syndrome. It involves lot of physical and emotional issues apart from financial problem. Hence it is very much necessary that you take help from support group with people who have similar challenges. You can ask your doctor or approach local health department for identifying such parents.

Progeria – Pictures, Symptoms, Causes, Treatment, Diagnosis

Progeria – Pictures, Symptoms, Causes, Treatment, Diagnosis

What is Progeria?

This is a genetic condition which is progressive and causes children to quickly age, starting in the 2 years in the beginning of life. This problem is extremely rare; in fact since 1886, there have been only 130 recorded cases in the medical literature. This disorder is also identified as Hutchinson-Gilford progeria syndrome.

Children with this condition, typically appear normal at birth. But by the age of 1, symptoms and signs, like changes in skin as well as loss of hair, start to develop. The life expectancy of a child with this disorder averages 13 years of age, but many with this problem usually die much younger and in some cases they can live to be 20 years old or even longer.

Stroke or problems with the heart is the usual reason for death in the majority of these children.

Progeria Symptoms

During the 1st year, the growth of any child with progeria begins to slow significantly and the weight as well as the height falls below normal for her/his age. The weight will fall low for height. Development of motor skills as well as mental growth will stay normal.

Symptoms and signs of this progressive condition include:

• Growth slows, with below average weight and height


• Beaked nose and narrowing face that makes the child look old


• Alopecia or hair loss which includes eyebrows as well as eyelashes


• Tightening and hardening of skin on trunk and extremities – known as Scleroderma


• Aged looking skin which is loose


• Scalp veins which are prominent


• Head too large for face


• Eyes which are prominent


• Micrognathia or small lower jaw


• Voice which is high-pitched


• Abnormal and delayed formation of teeth


• Loss of muscle and body fat


• Stiff joints


• Hip dislocation

It is important to see your child’s doctor if your child does not seem to be developing or growing normally, or has problems with loss of hair, changes in the skin or growth which is slowed.

The children with progeria normally develop atherosclerosis which is very severe. This is where the walls of the arteries, become stiff and thick, and begin to restrict the flow of blood. Many of these children die from the complications which are usually related to atherosclerosis, including:

• Cardiovascular problems which cause Heart Attacks as well as Congestive Heart Failure


• Cerebrovascular problems which result in stroke

Common signs of aging which occur less but can affect a child with progeria include:

• Cataracts


• Insulin resistance


• Tumors

Other problems with health that are linked to aging – for instance near-sightedness, Alzheimer’s disease, osteoarthritis – don’t develop as part of the aging process with progeria.

Progeria Causes

Scientists have revealed a single mutated gene to be the cause for Hutchison-Gilford progeria syndrome. This gene is referred to as lamin A or LMNA and it makes a protein which is needed to hold the nucleous of a cell together. These scientists believe that the mutation of this gene causes cells to be unstable and leads to progeria’s characteristic process of aging.

Progeria Treatment

There is no test to confirm progeria and no cure. Physicians normally make the diagnosis based on symptoms and signs – such as hair loss as well as not growing. These are normally not fully evident until about the age of 2.

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But, since the detection of the mutation of progeria, it is conceivable to use genetic testing for the LMNA mutations immediately if there is the suspicion of progeria. It stands to reason that the sooner the diagnosis is confirmed, the sooner the medical staff can begin treatments which can help to ease the symptoms as well as the signs of this disorder.

Another test using blood can reveal whether the child has a low level of high-density lipoprotein or HDL cholesterol, or the good cholesterol which helps keep the arteries open. The find is not diagnostic alone but can give support to a diagnosis of progeria.

As already stated, there is no cure for progeria. But there is management which can prolong the child’s life. The regular checking for cardiovascular disease can aid with managing this condition. In some cases, the child may experience bypass surgery for coronary arteries or angioplasty which is the expansion of cardiac arteries in order to slow the progress of cardiovascular disease.

Some therapies can help with the management of symptoms and signs. These include:

Aspirin in low dose
A daily dose to help with the prevention of stroke and heart attacks.

High-calorie supplements for diet
Including extra calories in the child’s daily diet can help in preventing loss of weight as well as ensure nutrition is adequate.

Occupational and physical therapy
These can aid stiffness in the joints and any problems with hips, and can allow the child to stay active.

Tubes for feeding
Infants who are feeding poorly can be helped with a feeding tube as well as a syringe. The syringe is used to push formula or breast milk thru the tube in order to make it much easier to feed the child.

Primary teeth extraction
The child’s permanent teeth will start to come in prior to his or her baby teeth falling out, therefore extraction can help stop any problems linked with the delay in losing baby teeth, such as developing a 2nd row of teeth or overcrowding when permanent teeth grow in.

Progeria Pictures