Liver is a small flesh colored organ found below the diaphragm and just above the stomach. Liver is one of the vital organs of our body which performs various functions like cleaning toxic materials from the blood, secreting Bile (indirectly helping digestion) and releases substances that helps in clotting of blood. But the major function of liver is filtration of blood for which the entire blood of the body should pass through it thus giving access for Cancerous cells to enter the liver easily.There are two types of Liver Cancer, one is primary liver cancer which begins in hepatocyte cells of the liver and the other is secondary liver cancer wherein cancerous cells starts elsewhere in the body and moves towards the liver. This is called Metastatic cancer which begins in the lungs or colon and gradually spreads to liver. Primary liver cancer targets elderly men rather than women.Liver cancer targets adults and elderly people but even teenagers can develop hepatoblastoma and hepatocellular liver cancer. Apart from cancer causing Tumors the liver can contain other types of masses or tumors that are benign (non-cancerous) like hepatic adenoma, Lipoma and fibroma. Such types of tumors (even not harmful) should be removed by surgery. Liver Cancer Symptoms :Often liver cancer would not show any symptoms until it matures and advances to high grade of cancer. Some of the common signs of liver cancer are loss of appetite, loss of weight (without any effort), stomach pain, nausea, vomiting and general weakness. For some people stomach would bulge forward due to swelling. Sometimes the skin becomes yellow color and even the eyes would turn yellow like Jaundice. Liver tumors can influence the normal level of sugar and calcium causing unwanted consequences.Causes :Exact reason of liver cancer is not known. It is believed to occur due to repeated liver infection like hepatitis virus. The cells of the liver normally undergo mutations in the genetic material in routine manner. But in rare cases these cells begin to multiply in uncontrolled fashion developing into a tumor causing cancer. Liver cancer can also develop due to over usage of alcohol and chronic infection. Some people are born with hemochromatosis (excess of iron in the liver) causing scarring of tissue which can lead to cancer. In rare cases Obesity and Fatty Liver disease can also cause liver cancer.Risk Factors :More men than women are prone to develop hepatocellular (primary liver cancer). Being over-weight, being diabetic, being Asian Americans, and born with inherited metabolic problems increases the risk of liver cancer. A person getting chronic hepatitis infection is likely to develop liver cancer. Alcohol abuse is one of the major causes of liver cancer in under developed countries.Diagnosis :Based on your symptoms, your doctor may request for series of testing procedure like blood test, liver function test, CT or MRI scan of the liver. To confirm the diagnoses, he might do a liver biopsy by removing a small tissue sample from the liver through a tiny needle. In developed countries screening tests are done for targeted people or people with high risk to detect liver cancer in early stages. Ultrasound of liver is done and alpha fetoprotein blood test may also be done for screening.Grading :Before deciding on the course of treatment, the doctor would determine the stage of liver cancer. This factor is crucial in determining the chance of survival of the patient. Liver cancer is graded from I to IV. Lower the number lesser is the risk and higher the number more is the risk. Grade 4 indicates the cancer has metastasized and spread to other tissues nearby.For the purpose of treatment, often doctors categorize the liver cancer in terms of “resectable” meaning there are still chances for removing cancer surgically. Potentially resectable cases are one that is healthy enough for surgical procedure of removing cancer. In case the tumor is smaller in size then the patient is grouped under potentially transplantable (Liver transplantation can be done). If the cancer cells are larger in size it cannot be operated by surgery it is known as unresectable and here the cancer has spread outside the liver also. Finally, some patients are not healthy enough for undergoing surgery even when the cancer is resectable they are grouped under “inoperable cases”. Grade 3 and 4 cases are at high risk and mostly the cancerous cells would have metastasized to other parts.Liver Cancer Treatment :Based on the factors like age of the patient, intensity of cancer, its growth and stage your doctor would make a decision and discuss with you to choose the best mode of treatment. Surgery, liver ablation, radiation, chemotherapy and targeted therapy are some of the options available for liver cancer. Many times combination of one or more treatment gives the best result.
- Surgery :
- Liver Transplantation :
- Ablation :
- Embolization :
- Radiation :
- Chemotherapy :
- Targeted Therapy :
- Alternative Approach :
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